Crosstalk from Adipocytokine signaling pathway to Insulin signaling pathway

List of curated literature with evidence for crosstalk from Adipocytokine signaling pathway to Insulin signaling pathway

  • Leptin secretion and negative autocrine crosstalk with insulin in brown adipocytes.

    • PubMed ID : 12379502
    • Molecule in Adipocytokine signaling pathway: LEP
    • Species : Homo sapiens
    • Transcription : unknown

    • Molecule in Insulin signaling pathway: unknown
    • Tissue : adipocyte
    • Regulation type : Inhibiting
    • Sentence from paper : This is the first report on direct leptin interactions with insulin signalling and action in brown adipocytes

  • Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor.

    • PubMed ID : 19047149
    • Molecule in Adipocytokine signaling pathway: LEP
    • Species : Homo sapiens
    • Transcription : no
    • Sentence from paper : We found a novel bidirectional crosstalk between leptin and IGF-I signaling; IGF-I induced phosphorylation of leptin receptor (Ob- Rb) and leptin induced phosphorylation of IGF-I receptor (IGF-IR)

  • The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes.

    • PubMed ID : 19183933
    • Molecule in Adipocytokine signaling pathway: LEP
    • Species : Homo sapiens
    • Transcription : no
    • Sentence from paper : We found a novel bidirectional crosstalk between leptin and IGF-I signaling; IGF-I induced phosphorylation of leptin receptor (Ob- Rb) and leptin induced phosphorylation of IGF-I receptor (IGF-IR)

  • Exploring the pathogenetic association between schizophrenia and type 2 diabetes mellitus diseases based on pathway analysis.

    • PubMed ID : 23369358
    • Molecule in Adipocytokine signaling pathway: LEP
    • Species : Homo sapiens
    • Transcription : unknown

    • Molecule in Insulin signaling pathway: insulin
    • Tissue : hypothalamus
    • Regulation type : Unknown
    • Sentence from paper : In our constructed STMN, we also observed a crosstalk between leptin and insulin in the hypothalamus

  • Glucagon-like peptide 1 interacts with ghrelin and leptin to regulate glucose metabolism and food intake through vagal afferent neuron signaling.

    • PubMed ID : 25833771
    • Molecule in Adipocytokine signaling pathway: LEP
    • Species : Homo sapiens
    • Transcription : no

    • Molecule in Insulin signaling pathway: GCG
    • Tissue : neuron
    • Regulation type : Activating
    • Sentence from paper : Specifically, leptin has been demonstrated to interact with GLP-1 and its receptor antagonist to induce satiation

Molecules mediating the crosstalk
Molecule in Adipocytokine signaling pathwayMolecule in Insulin signaling pathwayTissueSpeciesPubMed Identifier
LEPunknownadipocyteHomo sapiens12379502
LEPIGF1breast cancer cellHomo sapiens19047149
LEPIRS1breast cancer cellHomo sapiens19183933
LEPinsulinhypothalamusHomo sapiens23369358
LEPGCGneuronHomo sapiens25833771

Note: We direct each interaction from the molecule in the first pathway to the molecule in the second pathway. The direction of the interaction does not imply that the first molecule regulates the second molecule or that they directly interact. Hence, the interactions in this network may be indirect and may not indicate any mechanism.

Attribute NameDescription
Pathway A

The name of the upstream (first) pathway in a pair of crosstalking pathways.

Pathway B

The name of the downstream (second) pathway in a pair of crosstalking pathways.

Pubmed Query

The string used as a structured query in PubMed that returned the recorded PMID as a result.

PMID

The PubMed identifier for the reported publication.
We recorded "NO_RESULTS_FOR_PUBMED_QUERY" as a dummy PMID when the PubMed query returned no results.

Crosstalk

yes, if Pathway A elicits a downstream transcriptional response in Pathway B.
no, otherwise.

Transcriptional

yes, if the crosstalk is transcriptional.
no, otherwise.

Regulation type

The downstream effect on Pathway B. This attribute can take one of the following two values:

  • Activating: Stimulation of Pathway A up-regulates a gene or activates a protein that is representative of Pathway B.
  • Inhibiting: Stimulation of Pathway A down-regulates a gene or inhibits a protein that is representative of Pathway B.
Molecule A*

The molecule in Pathway A responsible for mediating crosstalk to Pathway B.

Molecule A Identifier

Unique identifier for Molecule A in the namespace recorded in "Molecule A Source", e.g., the UniProt ID of a protein.

Molecule A Source

The name of database that the value in "Molecule A Identifier" comes from, e.g., "UniProt" if the molecule is a protein.

Molecule B*

The molecule in Pathway B responsible for mediating crosstalk from Pathway A.

Molecule B Identifier

Unique identifier for Molecule B in the namespace recorded in "Molecule B Source", e.g., the UniProt ID of a protein.

Molecule B Source

The name of database that the value in "Molecule B Identifier" comes from, e.g., "UniProt" if the molecule is a protein.

Species

The name of the species in which the crosstalk was observed.

Tissue

The name of the tissue or cell line in which the crosstalk was observed.

BTO ID

The BRENDA Tissue Ontology (BTO) Identifier of the tissue or cell line in which the crosstalk was observed.

Condition

Notes on the experimental condition in the publication.

Sentence from paper

The sentence in the publication supporting the crosstalk. We record a sentence only if it states that Pathway A increases or decreases Pathway B signaling. The sentence may also include information about the proteins or genes responsible for mediating the crosstalk.

Misleading evidence for crosstalk

A sentence in the paper that appears to support evidence for crosstalk when the study does not conclude there is crosstalk.

Additional notes

A curator's notes that may provide rationale for the values recorded for the attributes.

*This attribute may represent either an individual molecule or several molecules. We use the following syntax for this attribute.

  • colon (:): The molecules participate in the complex, e.g., SMAD3:SMAD4 in the case of crosstalk from the TGF-beta signaling pathway to the Hippo signaling pathway (the complex consisting of SMAD3 and SMAD4 mediates this crosstalk).
  • slash (/): Either of the molecules can mediate the crosstalk, e.g., YAP1/WWTR1 for the same pair of pathways (YAP1 or WWTR1 can mediate the crosstalk).
  • comma (,): All the molecules are required for the crosstalk but they do not form a complex, e.g., TSC2,RPTOR for the crosstalk from the MAPK signaling pathway to the mTOR signaling pathway (both TSC2 and RPTOR act as mediators).
  • brackets ([]): If we cannot identify the specific molecule, we record all molecules in the family, e.g., [TEAD1/TEAD2/TEAD3/TEAD4]. In this case, the publication only listed the protein TEAD as mediating the crosstalk (from the Hippo signaling pathway to the Wnt signaling pathway).